Stavropoulos A, Divolis G, Manioudaki M, Gavriil A, Kloukina I, Perrea DN, Sountoulidis A, Ford E, Doulou A, Apostolidou A, Katsantoni E, Ritvos O, Germanidis G, Xilouri M, Sideras P. Sci Signal. 2022 JunClick here to read the article
Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of various non-infectious inflammatory and thrombotic diseases. We investigated the presence and possible associations of NETs with various histopathologic parameters in patients with non-alcoholic steatohepatitis (NASH). We retrospectively assessed 20 liver biopsy specimens from patients with non-alcoholic fatty liver disease (NAFLD), including 17 specimens with NASH,…
ΛεπτομέρειεςDiagnostic histological criteria for autoimmune hepatitis (AIH) have not been clearly established. Previously published criteria focused mainly on chronic AIH, in which inflammatory changes mainly occur in portal/periportal regions and may not be applicable to acute presentation of AIH, in which inflammatory changes are typically predominantly lobular in location. International consensus criteria for the diagnosis…
ΛεπτομέρειεςConsensus among international experts on response criteria and endpoints in autoimmune hepatitis is lacking. A consensus on endpoints is urgently required to set a global standard for the reporting of study results and to enable the comparison of results between clinical trials. Therefore, the International Autoimmune Hepatitis Group (IAIHG) herein presents a statement on 5…
ΛεπτομέρειεςScarce data exist on the effect of nucleos(t)ide analogue (NA) discontinuation on hepatocellular carcinoma (HCC) risk in HBeAg-negative chronic hepatitis B (CHBe−). Therefore, we assessed whether HCC risk is increased in non-cirrhotic CHBe− patients who discontinue compared to those remaining on NAs. Click here to read the article
ΛεπτομέρειεςTenofovir alafenamide fumarate (TAF) was shown equally efficacious in suppressing hepatitis B virus (HBV) but with less renal toxicity than tenofovir disoproxil fumarate (TDF). The aim of this real-world study was to evaluate renal function in post-liver transplantation (LT) patients that changed TDF with TAF. Click here to read the article
ΛεπτομέρειεςAs previous real-world studies and meta-analyses have shown that mycophenolate mofetil (MMF) might have better efficacy than azathioprine (AZA) in autoimmune hepatitis (AIH), we conducted a propensity matching study to assess the efficacy and safety of MMF vs. AZA. Click here to see the article
ΛεπτομέρειεςAutoimmune hepatitis (AIH) is a chronic non-resolving liver disease characterized by diffuse hypergammaglobulinemia, the presence of autoantibodies and characteristic histological findings. The disease can have catastrophic outcome with the development of end-stage liver disease if misdiagnosed/undiagnosed and leftuntreated. Click here to read the article
ΛεπτομέρειεςLittle is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in AIH peripheral lymphocytes at diagnosis and remission. Click here for the article
ΛεπτομέρειεςPichamol Jirapinyo P, et al. Clinical Gastroenterology and Hepatology 2022;20:511–524 ΠΕΡΙΛΗΨΗ Σκοπός: Η απώλεια σωματικού βάρους μέσω της αλλαγής του τρόπου ζωής παραμένει ο ακρογωνιαίος λίθος της θεραπείας της μη αλκοολικής λιπώδους νόσου του ήπατος (ΜΑΛΝΗ). Οι ενδοσκοπικές βαριατρικές και μεταβολικές θεραπείες (ΕΒΜΘ) έχουν προσφάτως αναπτυχθεί αποτελώντας μία εναλλακτική θεραπευτική επιλογή της παχυσαρκίας. Σκοπός αυτής…
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